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Thanks for your response. &nbsp;Could I save a snapshot in another datastore?
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Yes, but you would have to modify the location of the working snapshot folder.<br />
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Do not use snapshots as backups.<br />
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Do not keep a VM running on a snapshot for long than two days.<br />
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and please read my EE Article<br />
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<a href="https://www.experts-exchange.com/Software/VMWare/A_10300.html" rel="ugc">HOW TO: VMware Snapshots :- Be Patient</a><br />
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Snapshot cause performance issues!
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Is there a limit on the total number of HDs in the Virtual Machine when i do a SnapShot in vSphere 6. ie. more than one HD. <br />
Also is there any limitation on the size of the SnapShot on the second disk eg. If I have a VM with a second HD of &nbsp;10 TB LUN - would it be possible.
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Is there a limit on the total number of HDs in the Virtual Machine when i do a SnapShot in vSphere 6. ie. more than one HD. 
Also is there any limitation on the size of the SnapShot on the second disk eg. If I have a VM with a second HD of  10 TB LUN - would it be possible.

SnapShot Limit on vSphere 6.0

VMware, a software company founded in 1998,  was one of the first commercially successful companies to offer x86 virtualization. The storage company EMC purchased VMware in 1994. Dell Technologies acquired EMC in 2016. VMware’s parent company is now Dell Technologies.

VMware has many software products that run on desktops, Microsoft Windows, Linux, and macOS, which allows the virtualizing of the x86 architecture.  Its enterprise software hypervisor for servers, VMware vSphere Hypervisor (ESXi), is a bare-metal hypervisor that runs directly on the server hardware and does not require an additional underlying operating system.