Keyboard and Mouse work from BIOS, but not Windows

Client has fairly new HP Envy tower running Windows 10. Working fine until earlier today. In the middle of using it, USB Keyboard and Mouse stopped responding.  Both work at BIOS (entering setup with ESC). I can run keyboard and mouse diags from the BIOS, both pass. USB diags pass from the BIOS. Overall system test passes.

But as soon as I start to boot, nothing.

I can get into Safe Mode, but no keyboard or mouse there either.

I powered down, unplugged, pressed the power button for about 30 secs, left it unplugged for a while, tried different keyboard/mouse/usb ports... no joy. It gets to the Windows login screen but can't get ctrl/alt/del to be recognized.  There are no "traditional" mouse/keyboard ports to try... just USB.

I was able to get into the "fix my computer" screen at one point and did a System Restore from about a week ago, but that didn't fix anything.

It shows up on my network, but I can't remote desktop into it (probably not enabled).

Help ?
adladladlAsked:
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Joe Winograd, Fellow&MVEDeveloperCommented:
This problem has reached epidemic proportions. All of these relatively recent EE threads sound similar to your problem (but it's possible, of course, that yours is a different problem):

https://www.experts-exchange.com/questions/29084804/Strange-keyboard-and-mouse-issue-on-Dell-3020.html

https://www.experts-exchange.com/questions/29084840/USB-Mouse-Keyboard-not-working-Windows-10.html

https://www.experts-exchange.com/questions/29084880/USB-Ports-Not-Working.html

https://www.experts-exchange.com/questions/29084913/Windows-10-Updates-caused-USB-wired-keyboard-and-mouse-to-stop-working.html

https://www.experts-exchange.com/questions/29085190/Keyboard-and-Mouse-no-longer-allow-me-to-operate-my-PC.html

https://www.experts-exchange.com/questions/29085640/Keyboard-and-Mouse-not-working-of-several-machines.html

https://www.experts-exchange.com/questions/29085715/Mouse-and-Keyboard-stopped-working-on-DELL-desktop-PC.html

https://www.experts-exchange.com/questions/29085738/USB-devices-aren't-working-and-Malware.html

https://www.experts-exchange.com/questions/29085784/mouse-cursor-disappear-in-window-10.html

https://www.experts-exchange.com/questions/29086536/Keyboard-and-mouse-don't-work.html

The quick summary is to uninstall Windows update KB4074588.

Microsoft is well aware of the problem and even posted an article about it on Friday at the Windows support site showing two methods to resolve it:

https://support.microsoft.com/en-us/help/4091240/usb-devices-may-stop-working-after-installing-the-february-13-2018-upd

Regards, Joe
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JohnBusiness Consultant (Owner)Commented:
Also try to start in Safe Mode and update BIOS and Chipset drivers. This is part of the fixes.
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adladladlAuthor Commented:
Thank you, thank you !!!!  That worked!
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JohnBusiness Consultant (Owner)Commented:
If you have no more questions, can you close the question?  Thanks.
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Joe Winograd, Fellow&MVEDeveloperCommented:
You're very welcome. I'm glad that worked for you. As John has already requested, please close the question when you get a chance. Regards, Joe
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