Outlook 2016 disconnecting from Exchange

We are a small computer support company with onsite exchange 2016. Two of our computers with Windows 10 and Outlook 2016 from time to time disconnect from the exchange server and won't reconnect unless you restart the computer. They will stay connected for hours, sometimes for days, but once the disconnect occurs they will not reconnect without restarting the computer.  When the disconnect occurs GetAppManifests failed appears in the event log. Restarting Outlook in normal or safe mode gives the same error. After a computer restart, GetAppManifests succeeds and Outlook works normally until after several/many hours it suddenly disconnects again.
Pete SmithAsked:
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Valentina PerezExchange ServersCommented:

I see only two computers have this random disconnections?

Please try to repair Outlook appliaction.

Have you tried to create new profile?

Ibrahim BennaTechnology LeadCommented:
This seems more like a networking issue. Instead of rebooting next time, try to release and renew the IP address - does it reconnect?
Also, can you make sure your network drivers are up to date from the manufacturer?

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Pete SmithAuthor Commented:
Ok, I will try these suggestions and report back.... not had a disconnection today except first thing this morning before I put in the request for help. When this issue arises the network still seems to be working normally.. we can see our servers and internet, even so I will try each of the suggestions in turn. Thank you for your help.
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William WeickerCommented:
We are having the same problem with Outlook 2013. We tried EVERYTHING and ran every report we could but the problem still persist. I am stating to think that Microsoft is causing the problem. I find it odd that every network report, event log and packet tracing we did came back clean even though we are still having constant disconnects from multiple users. Please Help
Pete SmithAuthor Commented:
I have solved it and it was the "renew IP connections" from Ibrahim that got me to the right place. After it failed again today, I did the ipconfig /release, ipconfig /renew and ipconfig /all (so I could see all the IP information). The DHCP server and DNS server had the wrong address. With the wrong DNS server, Outlook couldn't find Exchange. Someone had been messing with our Untangle box a few months back and had managed to turn on its DHCP server. So, sometimes when a lease expired it picked up DHCP from the Untangle box so DNS was wrong and immediately Outlook stopped. Restart the PC and usually it got the right data from our Windows Server and everything worked again.

So, thank you Ibrahim for nudging me the right way!! So certainly worth checking with ipconfig!!
Ibrahim BennaTechnology LeadCommented:
Glad I was able to assist :)!
Pete SmithAuthor Commented:
Thank you everybody for your help. Problem is fixed now!
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