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Thnx Neeraj Sir for giving ur precious time and great support to this post <br />
Have a Great Day
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Thnx Neeraj Sir for giving ur precious time and great support to this post
Have a Great Day

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Highlighted colour is only for understanding purpose, in actual file there is no highlighted colour<br />
in the highlighted colour coloumn we have data &nbsp;but nothing to do with it <br />
we have to concentrate on coloumn C,D,E,F<br />
if alphabetical data is found &nbsp;then change the data to 124124<br />
see the result in sheet2<br />
I have putted the result in sheet2 but I want the result in same sheet not in sheet2<br />
See the sample file<br />
I have to do all this by vba<br />
<a href="https://filedb.experts-exchange.com/incoming/2018/07_w27/1347960/Sample-file3.xlsm" target="_blank" class="file-inline" title="if alphabetical data is found  then change the data to 124124(variation) (17 KB)"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path d="M67.508 468.467c-58.005-58.013-58.016-151.92 0-209.943l225.011-225.04c44.643-44.645 117.279-44.645 161.92 0 44.743 44.749 44.753 117.186 0 161.944l-189.465 189.49c-31.41 31.413-82.518 31.412-113.926.001-31.479-31.482-31.49-82.453 0-113.944L311.51 110.491c4.687-4.687 12.286-4.687 16.972 0l16.967 16.971c4.685 4.686 4.685 12.283 0 16.969L184.983 304.917c-12.724 12.724-12.73 33.328 0 46.058 12.696 12.697 33.356 12.699 46.054-.001l189.465-189.489c25.987-25.989 25.994-68.06.001-94.056-25.931-25.934-68.119-25.932-94.049 0l-225.01 225.039c-39.249 39.252-39.258 102.795-.001 142.057 39.285 39.29 102.885 39.287 142.162-.028A739446.174 739446.174 0 0 1 439.497 238.49c4.686-4.687 12.282-4.684 16.969.004l16.967 16.971c4.685 4.686 4.689 12.279.004 16.965a755654.128 755654.128 0 0 0-195.881 195.996c-58.034 58.092-152.004 58.093-210.048.041z"/></svg>Sample-file3.xlsm</a>
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if alphabetical data is found  then change the data to 124124(variation)

Sample-file3.xlsm

Highlighted colour is only for understanding purpose, in actual file there is no highlighted colour
in the highlighted colour coloumn we have data  but nothing to do with it 
we have to concentrate on coloumn C,D,E,F
if alphabetical data is found  then change the data to 124124
see the result in sheet2
I have putted the result in sheet2 but I want the result in same sheet not in sheet2
See the sample file
I have to do all this by vba

Microsoft Office is an integrated suite of applications that includes Outlook, Word, Excel, Access, PowerPoint, Visio and InfoPath, along with a number of tools to assist in making the individual components work together. Coding within and between the projects is done in Visual Basic for Applications, known as VBA.

Microsoft Office

Visual Basic for Applications (VBA) enables building user-defined functions (UDFs), automating processes and accessing Windows API and other low-level functionality through dynamic-link libraries (DLLs). VBA is closely related to Visual Basic and uses the Visual Basic Runtime Library, but it can normally only run code within a host application rather than as a standalone program. It can, however, be used to control one application from another via OLE Automation. VBA is built into most Microsoft Office applications.

Microsoft Excel topics include formulas, formatting, VBA macros and user-defined functions, and everything else related to the spreadsheet user interface, including error messages.

Microsoft Excel

Microsoft applications include a variety of software programs, including development and digital authoring programs (Expression and Media Center), educational programs, Internet software, including Essentials, Skype and the Live family, anti-virus, productivity applications and suites like Office, Excel, Word, Outlook, Access and PowerPoint, video games and server applications such as Exchange, SharePoint, IIS and Virtual Server.