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doughold

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Exchange Online Protection - Socket error code 10061

We use Exchange Online Protection for spam filtering Inbound and Outbound from our On-Premise Exchange hosting dozens of domains for customers. We are getting reports from end-users that their emails are being delayed and not received by the recipient for several minutes or hours. Running a message trace in Office 365 shows the following 'defer' message. These emails are being delivered to dozens of domains and recipients are not reporting issues with their setup.

Reason: [{LED=450 4.4.316 Connection refused [Message=Socket error code 10061] [LastAttemptedServerName=domain.com] [LastAttemptedIP=xxx.xxx.xxx.xxx:25] [CO1NAM05FT049.eop-nam05.prod.protection.outlook.com]};{MSG=Socket error code 10061};{FQDN=domain.com};{IP=xxx.xxx.xxx.xxx};{LRT=7/23/2018 6:58:29 PM}]. OutboundProxyTargetIP: xxx.xxx.xxx.xxx OutboundProxyTargetHostName: domain.com

This issue happened a couple month ago and eventually corrected. I have had a ticket opened with Office 365 for over a week now with no help from the level 1 tech I am dealing with. Anyone have an ideas on what is going on? Or any experience getting Office 365 to look at their setup?
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J0rtIT
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Step1. Make sure the domain is added into the O365 Admin panel.
Step2. Get the full rejected answer and use a service like mxtoolbox.com (Analyze Headers).

Usually, you get this when the domain is not added into the O365 panel, or if you have errors with the exchange online connectors. you do need to double check this. Also, you need to determine if it happens for one domain or all domains.
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doughold

ASKER

1: Yes, the domains are added to Office 365. This is happening to many domains but not for all emails.
2: We do not get a rejection, they are just delayed. Email goes from our Exchange > Office 365 > Recipient. Emails are accepted by Office 365 from our Exchange immediately then we may or may not get the defer notice and delay in the recipient receiving the email.
ASKER CERTIFIED SOLUTION
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Vasil Michev (MVP)
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Thanks, I have been trying to. I just spoke to the support rep again and demanded I speak to a supervisor, manager or this mysterious "internal team'  which I apparently I can't talk directly  to. She can't escalate the ticket until the internal team has all the information they are requesting which I feel will be never based on the inapplicable questions they are asking. They have asked if port 25 is open several times even though all the message traces I have provided show the email is received by a EOP server without issue and is a delivery issue.

I was hoping someone out there either when through, or is going through the same issue and could provide assistance on getting to the bottom of it.