Citrix XA 6.5 PVS Server Desktops sessions are getting disconnected. RDP to the xenapp server we see message saying "please wait for local session manager".

Citrix XA 6.5 PVS Server Desktops sessions are getting disconnected. RDP to the xenapp server we see message saying "please wait for local session manager".
Citrix Environment: Citrix XA 6.5
Provisioning : PVS 7.13
OS: Windows 2008 R2
Profile : Managed by appsense
Hypervisor : No virtual servers, all are physical server.

Problem Statement: We have issue were user desktops session are getting disconnected and on reconnecting they get aback screen. On trying RDP to the xenapp server we see message saying "please wait for local session manager". It stays that way for a while and after about 2-3 hours or so, comes back to life on its own. This is happening intermittently on maybe 1 or 2 servers in a day out of 70+ servers. The servers are not repeated either.

Troubleshooting: We had a new Vdisk rollout which had only MS patching done. The vdisk has worked fine for about 8-9days without any issues. KB4073578, KB4054521, KB4048960 , KB2483177  were the 4 patches that went in.
Have verified them and not getting any relevant known issues for these.
When server is stuck, tried to remotely connect to the services on the affected computer which was successful, stopped the appsense service and started back again, but no response. Event logs did not give much info either.
Murty MAsked:
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Dirk KotteSECommented:
do you reboot the servers daily, or do they run some days before getting the problem?
Which cache-mode do you use?
How about trying the previous PVS Image Version?
Murty MAuthor Commented:
1.We reboot alternate days. 50% estate on odd days and 50% on even days.
2. Ram cache with overflow to hdd
3. That is still not an option as only 2 servers get affected out of 80 servers. Also since vdisk is with security patch, roll back is not an option
Murty MAuthor Commented:
Hi Drik..  could you please check above answers.. and can you provide next step?
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Murty MAuthor Commented:
Hi Experts,
Still, we are facing the issue. Any suggestions?
Dirk KotteSECommented:

1. to many uptime ... not with 2 days max
2. Ram cache with overflow to hdd ... never seen problems with >= 7.13
3. if it is a problem really ... i would try the previous version (possible one security patch causes the problem)
... sometimes the AV causes problems ... pattern or version may change after reboot ...

i add some topics, because this problem may occur with RDP or other too.

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Murty MAuthor Commented:
Thank you.
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