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All Outlook clients failing to connect to Exchange 2016

Exchange 2016 CU9 DAG 2 Nodes
Windows 2016 Data Center
Outlook 2013/2016

Today I woke up and all my Outlook clients are disconnected from my Exchange 2016 Servers.

Restarting the clients did not help

starting outlook in safe mode did not help either

I can access the accounts via OWA

Hope I can resolve this before everyone gets in today

What can I look for?

Any commands?

Thank you in advance
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sara2000

I guess you already checked database mount status.
Have checked whether you have any DNS issue?
Also outlook connectivity?
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M A
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MAS

Thank you for your help

reverted back app pool change restarted IIS  now clients accessing
REopen this

Clients not connecting again

Exchange 2016 is crap