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Can you write more details about your porblem and provide some your code?<br />
If you use Microsoft Interop Excel you can set separator programmatically.<br />

<pre><code id="code-20-42686410-1"> Microsoft.Office.Interop.Excel.Application app = new Microsoft.Office.Interop.Excel.Application();
          string culture = System.Threading.Thread.CurrentThread.CurrentCulture.ToString();//&quot;en-GB&quot;;
            CultureInfo ci = new CultureInfo(culture);
          app.DecimalSeparator = ci.NumberFormat.NumberDecimalSeparator;
                app.ThousandsSeparator = ci.NumberFormat.NumberGroupSeparator;</code></pre>
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Can you write more details about your porblem and provide some your code?
If you use Microsoft Interop Excel you can set separator programmatically.


 Microsoft.Office.Interop.Excel.Application app = new Microsoft.Office.Interop.Excel.Application();
          string culture = System.Threading.Thread.CurrentThread.CurrentCulture.ToString();//"en-GB";
            CultureInfo ci = new CultureInfo(culture);
          app.DecimalSeparator = ci.NumberFormat.NumberDecimalSeparator;
                app.ThousandsSeparator = ci.NumberFormat.NumberGroupSeparator;

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How to resolve culture problem of decimal and thousand separator &nbsp;of number of excel using c#
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How to resolve culture problem of decimal and thousand separator  of number of excel using c#

culture issue in excel

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