Is it possible to force a GPO in a sub OU even if the parents OUs GPO has other settings of set?

In gpmc on sub ou level right click and click on block inheritance
This will stop flowing parent gpo on sub ou and sub ou level gpo will apply
Only thing parent ou gpo shouldn't be set to enforced, else block inheritance setting won't take effect

I don’t recommend blocking inheritance. Depending on the policy, specificity will apply the OU level policy and not the root one

I do not want to disable inheritance either.

Current situation:  
I have a GP at domain level which sets the proxy settings for IE.

Goal:
Now, we need to disable the proxy for some of our computers.

@Mahesh

Thank you for your solution. It would work that way, but disabling inheritance is not what I am looking for. If there is another way it would be great!

Change your IE policy to a GPO Registry preference that applies from the root. You can use item level filtering for the different settings

U are disabling inheritance for only single sub ou, this is simplest way to achieve what u r look for
Other ways are also there, but they need manipulation

There might be a bunch of non-enforced GPO at parent which would require relink.