I have ExaGear Desktop for Raspberry Pi 3 B+ and use WINE to successfully launch an x86 program. The x86 program needs to communicate with a device using a USB-serial adapter. So far I have not figured out how to get the x86 program to recognize the USB-serial adapter.
On a Windows laptop, we install USB Driver: CH341SER.exe and it just works without any troubleshooting or further configuration. I tried but it wasn't as simple as installing the CH341SER driver software using WINE on the Pi.
The endgame is to create a portable "black box programmer" to change motor control settings on my Bafang powered eBike.