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Intermittently cannot open Outlook - "The set of folders cannot be opened.  Network problems are preventing connection to Microsoft Exchange."

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Last Modified: 2018-12-28
Having intermittent issues opening Outlook 2016 and having it behave properly.   I will often get the following message when trying to open it - "Cannot start Microsoft Outlook. Cannot open the Outlook window.  The set of folders cannot be opened. Network problems are preventing connection to Microsoft Exchange."

Sometimes if I leave it closed for a little while, it will eventually then open again.   However, other mailboxes which I have full access permissions to  will not expand properly and kick back that similar message again.  Specifically, "Cannot expand the folder.  The set of folders cannot be opened...".  As an admin, I have full access permissions to various mailboxes, but most of them aren't expanding right now.  

Just to offer more background info, over the past several months we have been migrating from Exchange 2010 to 2016.   They are both still currently running, but most everything is routing to/through the new server.  Just have a few more mailboxes to migrate from 2010.   The specific mailbox in question here that is having issues is on 2016 and the client is running Outlook 2016.  It had been working OK, up until a couple weeks ago, well after having been migrated to the 2016 server.  I can't trace the origin of this issue back to a specific event, transition, migration, or whatever.

I do suspect that the issue is somehow more on the server side than the client side.  On the client side I have deleted the mailbox profile, run a repair on Office/outlook, restarted the computer, you name it...

Not sure what else to try or look for.  

Thanks in advance for any ideas or suggestions.
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