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What can cause Windows 10 to disassociate excel and PDF files with programs designed to open them?

A PDF icon loses its program association, I resolved the problem by creating a new PDF file then configuring it to open with Adobe Acrobat.
What can cause Windows 10 to disassociate excel and PDF files with programs designed to open them?
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Brian B
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Some other program may have tried to grab those files. you can find out which one in the registry, but if you have already fixed it no problem.
Generally this does not happen by itself.  On the user machine involved:

1. Scan fully for viruses and malware.
2. Make a new, test, Windows User profile (Account) using Users and Groups.   Test file association in the new Windows Account
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Thank you all