How to keep double-quote(") if string value contains it in vb.net

Sadly, your post is somewhat hard to read, so I'm not 100% sure what you mean.
I'll just tackle a few things, and hope it's enough to get you going.

"but some of them integer some of them different type."

That's very difficult to handle. I assume you want it all to finally all be in the String format, I hope?

dim a as Integer = 9
dim added_quotes = """" + a.tostring + """"

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Yes, there are 4 quotes in each group you see. As two are enclosing quotes for it to be a string. The other two inside the enclosing two are there, because you need to escape one quote for it to be a real quote inside the string.

"So first it should check has it contains " after that should keep them."

If you have read the cell string, and it was "eedm05__6924_.pdf", in memory it would be the same as

dim read_cell =  """eedm05__6924_.pdf"""

dim contains_quotes as Boolean = read_cell.Contains("""")

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As you can see, another set of 4 quotes, to check if a string contains one double quote.

If this doesn't help you at all, please provide some code you already have and explain some more about what you're trying to achieve.

I think my problem is different i thought because of that but my problem is COM program cannot recognize my strings and i checked documentation and found convert type of string like below;

E.g.

My string is like below;
Dim strComment As String = """ra1__Pulse-VF46-160__GH0072_112__180720.cgi"""

Output string should be like
 "\"ra1__Pulse-VF46-160__GH0072_112__180720.cgi\""