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Are 2 gpu better then 1 strong one?

2xRTX 4000 vs 1xRTX 5000?
Building a workstation for our creative team.

Do all the following software have the ability to us 2 cards? Is the thought process in saying 2 cards processing is more powerful then 1 correct?

Software used
1. Autodesk . 3DS max 2018
plugin (Vray 3.6 )
2. Adobe photoshop
3. Adobe illustrator
4. Adobe fuse
5. Adobe after effects
+ all the typical plugins
6. Cinema 4d
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John
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I have not seen this done. We have Adobe stuff running at one client, Autodesk and Adobe at another. One GPU and a very strong i7 CPU with lots of memory. No one is hampered.
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Two cards has the obvious advantage of not leaving you stranded if one fails, presuming you're using more than one monitor.  Generally speaking, two cards can outperform a single one, but there are too many variations of generation, SLI/Crossfire, and drivers to make a practical evaluation.

Cost and power requirements are cons to using two video cards versus one.

You might try building one of each, then running benchmarks from some of your manufacturers (Autodesk and Cinema 4D have them) to see which performs better for your specific needs.  Then just return the losing kit.
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Michael Elliott
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It's fairly rare for any software to leverage GPUs at this point.

Software leveraging multiple GPUs will likely be similar to finding a unicorn.

Before considering the correct investment into single or multiple GPU hardware, be sure to check specs carefully to ensure your software actually supports one or multiple GPUs.
bitcoin miners still will use multiple gpu's but since the serious player have moved onto using specialized asic's it's no longer cost effective.  I have 50 bitcoins in a wallet somewhere in my collection of disks. I've had them for almost 9 years.