Secure portable apps on a USB key

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What would you suggest as a secure portable desktop with portable apps to be installed on a USB key?
I have seen a suite which installs portable apps however it's easily accessible and the USB is not protected even with a password, which is dangerous.
Is there anything you recommend which is secure?
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Top Expert 2016
Commented:
use a usb key that has encryption. or encrypt with veracrypt or bitlocker

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Commented:
Veracrypt takes manual intervention unfortunately, but it works.
I was looking for seemless use.

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