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OK.... I mean you've not really given us any information on what you want done with this. You've not said if it's on a domain, you've not mentioned roaming profiles, you've not mentioned if any changes have been made which could have affected this.<br />
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Profiles don't randomly delete themselves and unfortunately you've given very little information for us to go on. Are there any other symptoms?
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Windows 10 - &nbsp;Users profile has disappeared not deleted very strange
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Windows 10 -  Users profile has disappeared not deleted very strange

Windows 10 Profile

Windows 10 is a personal computer operating system featuring the "universal application architecture" (UAP); apps can be designed to run across multiple devices with nearly identical code, including PCs, tablets, smartphones, embedded systems, Xbox One, Surface Hub and HoloLens. Windows 10 also includes a virtual desktop system, a window and desktop management feature called Task View, the Microsoft Edge web browser, support for fingerprint and face recognition login, voice-based search (Cortana), new security features for enterprise environments, and DirectX 12 and WDDM 2.0 to improve the operating system's graphics capabilities for games.

Windows 10

This topic area includes legacy versions of Windows prior to Windows 2000: Windows 3/3.1, Windows 95 and Windows 98, plus any other Windows-related versions including Windows Mobile.