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Outlook anywhere fails to connect. Exchange 2019 RPC: 1818 CallCancelled.

Last Modified: 2020-03-03
 Half a year ago i had got Exchange 2013 with RPC over HTTP ( Outlook anywhere) as main protocol.
 One day it failed for all external clients: outlook just wont connect,
 or connects but after 1-3 hours if outside of our corporate network.
 Testconnectivity showed  RPC: 1818 CallCancelled
 I ve tride everything but nothing helped to solve problem.
 Ive migrated to Exchange 2019.
 No cas or mailbox servers left from Exchange 2013.
 For nearly a month everything was fine, but one day, suddenly
 Outlook Anywhere failed again.
 Just the same bug and same error  RPC: 1818 CallCancelled.

Deployment: 2 Cas+Mailbox servers (both roles on each server) in DAG.
F5 big ip as router / firewall
SSL Bridging is ON on F5 , SSL offloading disabled in Exchange

Testconnectivity screenshot in attach.
What can i do and how to troubleshoot this bug?
Got any ideas?
Thx in advance.
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