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Deleting content with vhdx files

We have two session hosts within VMWare for users to connect to remote access. When logging in, a vhdx file is created and mounted for their profile. Is it safe to delete some of the contents of  vhdx files while they are not connected? (i.e. files within desktop folder). I don't intend to delete the vhdx files themselves but tidy up the contents of the folders, hoping this does not cause login issues the next time users reconnect. I am being overly cautious?

Many thanks
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Tony J
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Hi Lee, I was intending to keep the vhdx files but remove certain files within to moderate user behaviour regarding the location they save files. Primarily whether this was a safe exercise but also tied in with space saving as there is a growing trend to save unrelated work files on the desktop even though they have continually been told not to.
With a large number of people working from home, I'm trying to regulate this without effecting there ability to access RDS

Hope the additional info helps
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Thank you both for your help, I realised it would be unfair to ask outright 'is it safe to delete...'. I will continue to ask all staff to remove files from their desktops

Thanks again
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Much appreciated
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Tony J
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From a "it won't break the VHDX" perspective - it's the same as if it were a physical disk, of course. So as long as the files you deleted weren't system files then no reason it would bork it.

From a "will it impact the users" perspective, of course only you can answer that one :)
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VMware, a software company founded in 1998, was one of the first commercially successful companies to offer x86 virtualization. The storage company EMC purchased VMware in 1994. Dell Technologies acquired EMC in 2016. VMware’s parent company is now Dell Technologies. VMware has many software products that run on desktops, Microsoft Windows, Linux, and macOS, which allows the virtualizing of the x86 architecture. Its enterprise software hypervisor for servers, VMware vSphere Hypervisor (ESXi), is a bare-metal hypervisor that runs directly on the server hardware and does not require an additional underlying operating system.

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