troubleshooting Question

Deleting content with vhdx files

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LondonCallingFlag for United Kingdom of Great Britain and Northern Ireland asked on
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We have two session hosts within VMWare for users to connect to remote access. When logging in, a vhdx file is created and mounted for their profile. Is it safe to delete some of the contents of  vhdx files while they are not connected? (i.e. files within desktop folder). I don't intend to delete the vhdx files themselves but tidy up the contents of the folders, hoping this does not cause login issues the next time users reconnect. I am being overly cautious?

Many thanks
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