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Exchange not working after applying CU16

I tried to do an upgrade of my Exchange2016 server from Cu7 to Cu16.  It got all the way thru to and stopped at the "finishing up" stage.  I rebooted the server and then checked the version and it looked like everything upgraded to the correct version, but Outlook wouldn't connect.  I found an article that told me to do this:
 
Copied sharedWebConfig.config file from C:\Program Files\Microsoft\Exchange Server\V15\FrontEnd\HttpProxy directory.
Pasted sharedWebConfig.config file in C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess directory
IISreset /noforce
 
Now Outlook connects but it doesn't appear to be sending or receiving emails.  Can I run the CU install again?
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FOX
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Did you reboot the server after installing the CU?  Did you restart the outlook client as well.
Feel free to rerun the CU with powershell.
Scroll to the bottom of this link for the command

ref link:  https://docs.microsoft.com/en-us/exchange/plan-and-deploy/install-cumulative-updates?view=exchserver-2019
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So I ran it again and now Outlook won't connect again.  OWA connects but no mail is sending or receiving.

I did restart the server and the client after running it again.

Any other suggestions?
Did you verify if the outlook client has the latest updates? What version of outlook is it? 2013/2016?
Find the latest outlook client updates below:

ref link:  https://docs.microsoft.com/en-us/officeupdates/outlook-updates-msi
Now I am seeing that the state of many of my Server Components are Inactive.  I was able to set a bunch of them by using the command set-ServerComponentState - Identity (server) -Component ServerWideOffLine so now most of them are in the Active State, but still can't connect with Outlook.  Also when I try Get-ServerHealth it tells me the state is Unknown
Found that and followed the instructions.  Still have problem of State Unknown.  It now sends but doesn't receive.
Send screenshot of what is unknown.  Did you reboot after you followed those instructions?
There may be another file you need to delete, I found it in this article
ref link:   http://msexchangeworld.com/?p=314
To resolve this issue

Open the regedit and find watermark key and Buildtobuildupgrade key.
Delete watermark key and Buildtobuildupgrade key from Exchange Server.

Note:- Don’t forget to take registry backup before performing above steps.

After that run below Exchange setup Command from Exchange setup Folder.

setup /prepareAD /IAcceptExchangeServerLicenseTerms

After running prepareAd, check Exchange server component and health reports.
Ok, now I've got a health report which is telling me that the HubTransport is Degraded... But everything else is healthy.  Still can't receive email.
I deleted the watermarkkey but did not find the Buildtobuildupgrade key
Looks like it was a transient issue as now it is showing healthy, but still no incoming email
Are messages building up in your message queues? Or do you mean no mail is coming just to this outlook client
Nothing in queues
Is every Exchange 2016 server on the same CU?
Secondly on every exchange server open Exchange Management Shell and run the below command
Restart-Service MSExchangeTransport

ref link:  https://www.codetwo.com/kb/restarting-exchange-2007-transport-service/
There is only one Exchange server in the environment.
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Ok it finally worked!  I think the main issue at the end was I ran out of disk space on my C: drive.  Once I freed up some space mail started flowing!  Thank you sooo much for your help!
Again, thank you sooo much for sticking with me thru this process!
Oh you never said you ran out of space...Very good.  I'm glad you are up.