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smtp relay server in-place upgrade from 2008 to 2012

We have a Win 2008 R2 smtp relay server (configured in IIS 6.0 Manager).  We need to upgrade it to 2012 R2.  If I do this in-place upgrade will it break smtp relay and will I need to reconfigure it within 2012 R2?
Windows Server 2012Windows Server 2008

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8/22/2022 - Mon