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Shai

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Exchange 2016 EAC -- cannot handle the request error 500 for some admin accounts

some admin users cannot access exchange 2016 EAC (/ecp or /owa)
once logged in getting unable to handle the request error 500

it happens only for two admin accounts, also found that for them url /ecp redirects them to https://CAS/owa/auth.owa
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Michael B. Smith
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do they have mailboxes? are permissions inheriting on their AD accounts?
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Shai

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I am mot sure if they had mailbox and what was changed to them since it worked before.on my account there is a mailbox and it works for me. Not sure if its related.
About inheritance i dont know 
Yep - its very likely to be inheritance.

Open AD, go to the affected user, Security | advanced - Click "enable inheritance" - ok - then accept the warning message.

Wait approx 15 mins after this has been completed - and try again.
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but what if it worked before?
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Inheritance didnt make any change 
did you recently install a patch? the mailbox requirement is not supposed to be present, but it's been on-again/off-again ever since Exchange 2000 was released.
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Yes the latest april 2021 security patches 
Do the account names have a $ in them?
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Shai

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as i wrote before: the mailbox requirement is not supposed to be present, but it's been on-again/off-again ever since Exchange 2000 was released.