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DUO and OWA - Overall Affects

About to install the DUO OWA application on an on-premise exchange server and need to understand better the following:
- is there and option to remove DUO/2FA for some users while allowing it for others.
- how will it effect mobile phones already connected to exchange
- will it affect Outlook running on local computers
- anything else that may affect the overall on-premise exchange installation and end users. For obvious reasons don't want to create downtime prior to installation. 
ExchangeWindows Server 2019Security

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Seth Simmons

8/22/2022 - Mon