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Does your user have access rights to the msdb ? &nbsp;Look at the datbase - Security - Users and check whether your user has "DatabaseMailUserRole" and "db_owner" under "Membership" and also have Alter, Control and Execute for the stored procedure created to send the mail. 
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Alex A

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msdb.dbo.sp_send_dbmail&nbsp; Msg 22050, Level 16, State 1, Line 27 Failed to initialize sqlcmd library with error number -2147467259. why can't I send email using sp_send_dbmail&nbsp; ?how to add myself to existing @profile_name ? Thank you. 
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msdb.dbo.sp_send_dbmail 
Msg 22050, Level 16, State 1, Line 27
Failed to initialize sqlcmd library with error number -2147467259.
why can't I send email using
sp_send_dbmail
  ?
how to add myself to existing @profile_name ?
Thank you.

SQL Server: error when using sp_send_dbmail

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