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Unable to relay CRM email

Last Modified: 2012-05-09
Everything was fine, now all of a sudden:

#61042 - an error occurred while processing the outgoing email message with subject "" for smtp:xx for delivery through "exchange server". System.net.mail.smtpfailedrecipientexception: mailbox unavailable. The server response was: 5.7.1 unable to relay at system.net.mail.smtptransport.sendmail (mailaddress sender mailaddresscollection recipients, string deliverynotify, smtpfailedrecipientexception& exception) at system.net.mail.smtpclient.send(mailmessage message) at microsoft.crm.tools.email.providers.smtppollingsendemailprovider.processmessaginternal (email email message) at microsfot.crm.tools.email.providers.crmpollingsendemailprovider.run()

Any thoughts?

exchange 2007
server 2008
Microsoft CRM Dynamics
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