Hi,

Yes I am aware of how to limit the cache use via ADSI. Will that have any affect on users?

No, the server is not up to date.

If the server has 32gb of RAM (for example) then you should expect Exchange to take most of it.
However if something else wants the memory then it should give it back when asked for. If that isn't happening (which it seems is the case here) then you need to look at why.

Limiting the memory that Exchange can take isn't the answer, because it just deals with the symptom, not the cause.

What has changed recently? Has something new been installed on the server?
The usual cause of this kind of problem is something like AV or antispam software which hooks in to Exchange. Backup software I have seen do it as well.
If you have AV on the server, ensure that it has the correct exclusions for Exchange configured.

Simon.

It may effect delivery for a moment when you restart the store.exe service but as long as you give it enough, it shouldn't be a problem.

OK.

if you want to limit the Database Cache to 4 GB of an Exchange 2010 server, set msExchESEparamCacheSizeMax to 131072 (4 GB = 4.194.304 KB / 32 KB).

So based on this, if I want to limit the cache use to 15GB, then I would set the msExchESEparamCacheSizeMax to 491520 ?

If the server isn't up to date, then you should update it before you start playing around with settings that Microsoft do not recommend. A lot of issues like this are resolved in Exchange service packs and rollups, particularly with third party products being the main cause.

Simon.

I've updated the server. store.exe still using the same amount of RAM.

This blog will help you.

http://blogs.technet.com/b/maliks/archive/2012/04/25/exchange-2010-store-exe-service-takes-high-memory-utilization.aspx

http://social.technet.microsoft.com/Forums/en-US/5acb6e29-13b3-4e70-95d9-1a62fc9304ac/sbs-2011-storeexe-allocating-too-much-memory-despite-cache-adjustment?forum=smallbusinessserver